Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 19 Issue 12, December 2021

‘Hold your breath’, inspired by the Review on p774.

Cover design: Philip Patenall

Volume 19 Issue 12


  • The SARS-CoV-2 pandemic has seen a notable global reduction in influenza cases of both influenza A and B viruses. In particular, the B/Yamagata lineage has not been isolated from April 2020 to August 2021, suggesting that this influenza lineage may have become extinct, which may provide opportunities for improving availability and effectiveness of influenza vaccines.

    • Marios Koutsakos
    • Adam K. Wheatley
    • Steve Rockman




Top of page ⤴

Research Highlights

  • The authors of this study designed a novel therapeutic class of antimicrobials in which they optimized drug binding and permeation of the drug through bacterial membrane transporters simultaneously.

    • Megan Cully
    Research Highlight
  • Two recent studies provide mechanistic evidence that members of the microbiota cooperate to confer colonization resistance against pathogens.

    • Ashley York
    Research Highlight
  • This study finds that a tick symbiont modulates serotonin levels in the host and thus promotes blood feeding.

    • Ursula Hofer
    In Brief
Top of page ⤴

News & Analysis

  • This month’s Genome Watch highlights the need for improved phenotypic approaches to complement the power of genomics.

    • Caroline Zellmer
    • Tuan Anh Tran
    • Sushmita Sridhar
    Genome Watch
Top of page ⤴


  • There is considerable variability in antimicrobial pharmacokinetics and pharmacodynamics, which can pose challenges for treatment of infection and antimicrobial resistance development. In this Review, Holmes and colleagues discuss how precision antimicrobial therapy, including biosensors and individualized treatment, can contribute to antimicrobial stewardship.

    • Timothy M. Rawson
    • Richard C. Wilson
    • Alison H. Holmes
    Review Article
  • Human cytomegalovirus (HCMV) infection is ordinarily controlled by a vigorous immune response; however, HCMV can replicate to high levels and cause end organ disease when the immune system is compromised. In this Review, Griffiths and Reeves discuss HCMV pathogenesis in immunocompromised individuals and emerging strategies to treat and prevent infection and disease.

    • Paul Griffiths
    • Matthew Reeves
    Review Article
  • Hypoxic environments in which anaerobes dwell experience episodic oxygenation, which can be toxic to these organisms, yet many anaerobes have the capacity to tolerate substantial levels of oxygen. In this Review, Lu and Imlay explore the molecular mechanisms by which oxygen impairs anaerobic bacteria and the degree to which anaerobic bacteria protect themselves from oxidative stress.

    • Zheng Lu
    • James A. Imlay
    Review Article
Top of page ⤴


Quick links