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Illuminating the mechanism of monogenic antigen expression in trypanosomes

Nature Reviews Microbiology volume 19, page 746 (2021)Cite this article

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This month’s Under the Lens discusses how recent advances in understanding the spatial integration of transcription and splicing sites have shed light on the mechanism that ensures monogenic antigen expression in trypanosomes.

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References

  1. Horn, D. Antigenic variation in African trypanosomes. Mol. Biochem. Parasitol. 195, 123–129 (2014).

    Article  CAS  Google Scholar 

  2. Navarro, M. & Gull, K. A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei. Nature 414, 759–763 (2001).

    Article  CAS  Google Scholar 

  3. Faria, J. et al. Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes. Nat. Microbiol. 6, 289–300 (2021).

    Article  CAS  Google Scholar 

  4. Kassem, A., Pays, E. & Vanhamme, L. Transcription is initiated on silent variant surface glycoprotein expression sites despite monoallelic expression in Trypanosoma brucei. Proc. Natl Acad. Sci. USA 111, 8943–8948 (2014).

    Article  CAS  Google Scholar 

  5. Escobar, L. L. et al. Monoallelic antigen expression in trypanosomes requires a stage-specific transcription activator. Preprint at bioRxiv https://doi.org/10.1101/2021.05.06.442931 (2021).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, University of Oxford, Oxford, UK

    Patryk Ludzia & Bungo Akiyoshi

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  1. Patryk Ludzia
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  2. Bungo Akiyoshi
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Correspondence to Patryk Ludzia or Bungo Akiyoshi.

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The authors declare no competing interests.

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Ludzia, P., Akiyoshi, B. Illuminating the mechanism of monogenic antigen expression in trypanosomes. Nat Rev Microbiol 19, 746 (2021). https://doi.org/10.1038/s41579-021-00641-5

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  • DOI: https://doi.org/10.1038/s41579-021-00641-5

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