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To harness the potential of microbiome science across the broad range of relevant disciplines, new approaches to data infrastructure and transdisciplinary collaboration are necessary. The National Microbiome Data Collaborative is a new initiative to support microbiome data exploration and discovery through a collaborative, integrative data science ecosystem.
Two papers now report compound uptake in Mycobacterium tuberculosis by ATP-binding cassette (ABC) exporters, which are usually involved in the export of substrates out of the cell and which could be new drug targets.
A recent study found that bacterial volatile organic compounds attract springtails to soil-dwelling Streptomyces species, promoting the dispersal of spores.
This study finds that Neisseria gonorrhoeae suppresses epithelial exfoliation by nitric oxide-mediated initiation of a host signalling pathway to promote colonization in mice.
A recent analysis concludes that there is little evidence to support the notion that reservoir host affects the propensity for a virus to infect humans.
This month’s Under the Lens discusses recent advances in spatial metabolomics and light-sheet microscopy for imaging the biogeography of host–microbiota interactions.
In this Review, Berman and Krysan define and distinguish resistance and tolerance, and discuss the current understanding of the molecular, genetic and physiological mechanisms that contribute to those phenomena. Distinguishing tolerance from resistance might provide important insights into the reasons for treatment failure in some settings.
Worldwide amphibian declines caused by pathogenic chytrid fungi are emblematic of the emerging infectious diseases driven by globalization. Fisher and Garner discuss how these wildlife pathogens emerge to drive global declines in amphibian biodiversity and the implications of current research for policy and control measures.
Over the past decade, Klebsiella pneumoniae has emerged as a major clinical and public health threat. In this Review, Wyres, Lam and Holt discuss how genomics approaches have advanced our understanding of K. pneumoniae taxonomy, ecology and evolution as well as the diversity and distribution of clinically relevant determinants of pathogenicity and antimicrobial resistance.
