This month’s Genome Watch discusses the application of spatial transcriptomics to investigate the arrangements of microbial communities and their effects on the host.
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References
Ståhl, P. L. et al. Visualization and analysis of gene expression in tissue sections by spatial transcriptomics. Science 353, 78–82 (2016).
Saarenpää, S. et al. Spatial metatranscriptomics resolves host–bacteria–fungi interactomes. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01979-2 (2023).
Lötstedt, B. et al. Spatial host–microbiome sequencing reveals niches in the mouse gut. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01988-1 (2023).
Geier, B. et al. Spatial metabolomics of in situ host–microbe interactions at the micrometre scale. Nat. Microbiol. 5, 498–510 (2020).
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Blow, M.J. Mapping the microbiome milieu. Nat Rev Microbiol 22, 190 (2024). https://doi.org/10.1038/s41579-024-01019-z
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DOI: https://doi.org/10.1038/s41579-024-01019-z
