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It has recently been suggested that p53, which regulates the survival and metabolism of host cells, is commonly manipulated by intracellular bacterial pathogens. In this Progress article, Siegl and Rudel discuss mechanisms of p53 manipulation and consider the consequences for pathogenesis.
Viral apoptotic mimicry, defined by the exposure of phosphatidylserine on the pathogen surface, is emerging as a common theme used by enveloped viruses to promote infection. In this Progress article, Amara and Mercer discuss how viruses acquire phosphatidylserine and how this mimicry might facilitate cell entry and evasion of the immune response.
The archaeal genome is organized by either eukaryotic-like histone proteins or bacterial-like architectural proteins. Dame and colleagues discuss the interplay between chromatin proteins and components of the basal and regulatory transcription machinery, and describe how these factors cooperate in nucleoid structuring and gene regulation.
