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In this Journal Club, Ricardo Soto-Rifo discusses a study on intron-containing HIV-1 RNA, revealing its role as a pathogen-associated molecular pattern in myeloid cells, which has implications for immune activation, inflammation and clinical outcomes.
In this Journal Club, Salvador Almagro-Moreno discusses a study by Kirn et al., which explores the emergence of virulence traits in Vibrio cholerae and demonstrates how the ability of this pathogen to colonize the host shares a common mechanism to its capacity to thrive in natural environments.
In this Journal Club, Amelia Barber discusses a study revealing intraspecies heterogeneity in a fungal pathogen, prompting us to re-evaluate the notion of ‘reference’ strains.
In this Journal Club, Gonzalo Moratorio discusses a study using deep mutational scanning (DMS) to uncover how the influenza virus evades the host immune response, highlighting the potential of DMS in understanding the evolutionary arms race between pathogens and hosts.
In this Journal Club, Anja Spang discusses the discovery of nanosized archaea, transforming our knowledge of archaeal phylogeny and shedding light on their roles in ecology and evolution.
In this Journal Club, Chelsey Spriggs discusses how the study of simian virus 40 (SV40) revealed a key sequence in the large T antigen that directs its transport into the cell nucleus, advancing our understanding of nuclear import mechanics.
In this Journal Club, Edmund Loh explores the pioneering work of Jun-Ichi Tomizawa and colleagues, which uncovers the importance of a small RNA in plasmid replication and elucidates its mechanism of action.
In this Journal Club, Lisa Maier explores Abigail Salyers’ groundbreaking research on Bacteroides thetaiotaomicron, focusing on how she established a new genetic system and investigated how these gut bacteria bind and use starch, uncovering important insights into their metabolism.
In this Journal Club, Rebecca Shapiro discusses the discovery of the earliest antifungal drug, nystatin, by pioneering women Elizabeth Hazen and Rachel Brown.
In this Journal Club, Tao Zuo discusses a study by Gogokhia et al. who found that gut bacteriophages can alter mucosal immunity to impact mammalian health.
In this Journal Club, Sarah Auburn discusses the pioneering development of the first framework for whole-genome sequencing of natural malaria infections, revolutionizing malaria genomics.
