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The global spread of H5N1 avian influenza virus has raised concerns that H5N1 might adapt to the human host and cause the next human influenza pandemic. Novel glycan array technologies can rapidly assess the receptor specificity of influenza viruses, detecting changes that might signal human adaptation.
Highly active antiretroviral therapy (HAART) has had a major impact on the clinical management of HIV-1 infection. However, the emergence of resistant variants requires that follow-up drug regimens be optimized to maximum therapeutic effect. This article focuses on bioinformatics approaches that can be used to support anti-HIV therapy.
This article outlines the recently developed reverse-genetics systems for Borna disease virus (BDV), which will provide a powerful tool for the investigation of thecis-acting signals and trans-acting factors that control BDV RNA replication and gene expression.
