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In response to certain environmental cues, the unicellular budding yeastCandida albicanscan also grow as either a pseudohyphal or a hyphal form. In this Review, Sudbery describes the signal transduction pathways and cellular mechanisms that drive polarized hyphal growth and the role of this growth in disease.
The response from the scientific community to two recent controversies has shown that although scientific progress is not always linear, the right answer will emerge in the end.
The increased virulence ofLeishmania amazonsis compared with Leishmania major may result from the ability of L. amazonensisto induce the macrophage inhibitor CD200.
Our monthly round-up of infectious diseases news, which this month includes bacteria on the beach, good news about the HPV vaccine, copper in intensive care units and a scarlet fever outbreak in Hong Kong.
In bacteria, oscillations control numerous fundamental processes, including gene expression, cell cycle progression, cell division, DNA segregation and cell polarity. In this Review, Lenz and Søgaard-Andersen describe the design principles and mechanisms that underlie both temporal and spatial bacterial oscillators.
Hfq is a bacterial RNA-binding protein that participates in post-transcriptional control of gene expression by facilitating the interactions between small non-coding RNAs and their target mRNAs. In this Review, Vogel and Luisi describe the structural and functional features of this protein and discuss possible mechanisms of Hfq-mediated regulation.
A 7,000-year record of the population dynamics of a single-celled alga and its viruses has been reconstructed from ancient DNA extracted from marine sediments.
Two articles decribe fungal effectors that change the transcriptional response of the host plant to promote the establishment of a symbiotic relationship.
This month's Genome Watch discusses the methods and implications of recent rapid sequence analyses of outbreak strains ofEscherichia coli and Vibrio cholerae.
The scale of life in the microbial world is such that amazing numbers become commonplace. These numbers can be sources of inspiration for those in the field and used to inspire awe in the next generation of microbiologists.
Our monthly round up of infectious diseases news, which this month includes the use of Twitter to track public health, a call to ban tuberculosis blood tests, genetically modified organisms to fight HIV, and the outbreak ofEscherichia coliin Germany.
Technological advances have revealed many new aspects of bacterial transcription. In this Review, Serrano and colleagues describe the changes in our understanding of bacterial transcription and how this has revealed complexity of regulation that is similar to that observed in eukaryotes.
