Volume 9 Issue 8, August 2008

From The Editors

Research Highlights


  • Review Article |

    Cells are highly complex structures, but where does this complexity come from? Self-organization principles combined with simple physical constraints seem to control organelle size, number, shape and position. These factors then combine to give rise to the overall cell architecture.

    • Susanne M. Rafelski
    •  & Wallace F. Marshall
  • Review Article |

    Nectins and nectin-like molecules (Necls) are transmembrane cell adhesion molecules that have recently been shown to have a variety of cellular functions. They have roles in cell–cell adhesion, differentiation, polarization and survival, as well as in contact inhibition of cell movement and proliferation.

    • Yoshimi Takai
    • , Jun Miyoshi
    • , Wataru Ikeda
    •  & Hisakazu Ogita
  • Review Article |

    ATR kinase and the related ATM kinase have overlapping but non-redundant functions in the DNA-damage response that maintains genome integrity. ATR signals to regulate DNA replication, cell-cycle transitions and DNA repair through the phosphorylation of various substrates.

    • Karlene A. Cimprich
    •  & David Cortez
  • Review Article |

    The hypothesis that “tumor production is a possible overhealing” has recently been verified in several studies. In vivo analysis of genes that are involved in tissue repair combined with gene-expression analysis in wounds and tumours have highlighted remarkable similarities between wound healing and cancer.

    • Matthias Schäfer
    •  & Sabine Werner
  • Review Article |

    The ingestion of particles or cells by phagocytosis and of fluids by macropinocytosis requires cup-shaped invaginations of the plasma membrane. Common signalling mechanisms and distinct signalling patterns characterize the different stages of the formation of phagocytic and macropinocytic cups.

    • Joel A. Swanson



  • Opinion

  • Opinion |

    Tumour-necrosis factor receptor-1 (TNFR1) and CD95 can transduce pro-apoptotic and anti-apoptotic signals, but what determines the specificity of signalling events? It is possible that the endosomal compartment functions as a signalling organelle that selectively transmits death signals from TNFR1 and CD95.

    • Stefan Schütze
    • , Vladimir Tchikov
    •  & Wulf Schneider-Brachert