Volume 18 Issue 8, August 2017

Volume 18 Issue 8

'Joining non-matching ends' by Caio Bracey, inspired by the Review on p495.

Research Highlights



  • Review Article |

    Blood and lymphatic vessels have essential roles in physiology and disease. The endothelial cells that line these vessels specialize to fulfil the needs of the tissue that they pervade. Recent studies in animal models have provided insights into the mechanisms underlying vessel type- and organ-specific specialization, which is crucial for the understanding of several diseases.

    • Michael Potente
    •  & Taija Mäkinen
  • Review Article |

    In mammalian cells, DNA double-strand breaks (DSBs) are repaired predominantly by the non-homologous end joining (NHEJ) pathway, which includes subpathways that can repair different DNA-end configurations. Furthermore, the repair of some DNA-end configurations can be shunted to the auxiliary pathways of alternative end joining (a-EJ) or single-strand annealing (SSA).

    • Howard H. Y. Chang
    • , Nicholas R. Pannunzio
    • , Noritaka Adachi
    •  & Michael R. Lieber


  • Review Article |

    The termination of DNA replication involves convergence of replication forks, the completion of DNA synthesis, replisome disassembly and the decatenation of daughter DNA molecules. Recent discoveries illustrate how replisome disassembly in eukaryotes is controlled by E3 ubiquitin ligases and how this activity is regulated to avoid genome instability.

    • James M. Dewar
    •  & Johannes C. Walter