Volume 18 Issue 6, June 2017

Volume 18 Issue 6

'Dynamic rafts' by Vicky Summersby, inspired by the Review on p361.

Comment

Research Highlights

  • Research Highlight |

    Worms with impaired H3K4 trimethylation have an extended lifespan, which is associated with the accumulation of monounsaturated fatty acids in their intestines.

    • Kim Baumann
  • Research Highlight |

    The ESCRT-III complex is shown to counteract the loss of plasma membrane integrity in cells undergoing necroptosis, thereby preventing or delaying cell death.

    • Paulina Strzyz
  • Research Highlight |

    An isoform of the RNA-editing protein ADAR1 is shown to be activated through nuclear export in response to cellular stress and to protect anti-apoptotic mRNAs from Staufen 1-mediated decay.

    • Eytan Zlotorynski
  • Journal Club

Reviews

  • Review Article |

    The heat shock protein 90 (HSP90) chaperone machinery is a key regulator of proteostasis. Recent progress has shed light on the interactions of HSP90 with its clients and co-chaperones, and on their functional implications. This opens up new avenues for the development of drugs that target HSP90, which could be valuable for the treatment of cancers and protein-misfolding diseases.

    • Florian H. Schopf
    • , Maximilian M. Biebl
    •  & Johannes Buchner
  • Review Article |

    Lipid rafts are relatively ordered membrane domains that are enriched in cholesterol and saturated lipids, and selectively recruit other lipids and proteins. They are dynamic and heterogeneous in composition and are thus challenging to visualize in vivo. New technologies are providing novel insights into the formation, organization and functions of these membrane domains.

    • Erdinc Sezgin
    • , Ilya Levental
    • , Satyajit Mayor
    •  & Christian Eggeling
  • Review Article |

    Planar cell polarity — the asymmetric distribution of proteins in the plane of a cell sheet — dictates the orientation of various subcellular structures and drives collective cell rearrangements. Better understanding of this conserved axis of polarity can shed light on the mechanisms of morphogenetic processes and explain the underlying causes of human birth defects.

    • Mitchell T. Butler
    •  & John B. Wallingford

Perspectives

    Opinion

  • Opinion |

    In animal cells, actin is dynamically distributed between multiple coexisting arrays. Carlier and Shekhar propose that a global treadmilling process — whereby the various actin networks grow and shrink depending on the local activity of actin regulators — establishes a steady-state concentration of actin monomers that supports this homeostatic actin turnover.

    • Marie-France Carlier
    •  & Shashank Shekhar