Volume 17 Issue 10, October 2016

Volume 17 Issue 10

'Branching vessels' by Vicky Summersby, inspired by the Review on p611.


  • Comment |

    Sibon and Strauss discuss literature suggesting that cells can obtain intracellular coenzyme A by pathways in addition to de novo biosynthesis.

    • Ody C.M. Sibon
    •  & Erick Strauss

Research Highlights


  • Review Article |

    Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are crucial for the formation and remodelling of blood vessels. VEGFR2, which is the main endothelial VEGFR, is regulated by receptor-interacting proteins, endocytosis and trafficking. Recent insights have been gained into these layers of regulation and the crosstalk between VEGFR2 signalling and other endothelial signalling cascades.

    • Michael Simons
    • , Emma Gordon
    •  & Lena Claesson-Welsh
  • Review Article |

    Protein ubiquitylation has important regulatory functions, influencing protein–protein interactions and protein stability. The final step of ubiquitylation is catalysed by ubiquitin ligases (E3s), a diverse group of proteins that operate with distinct mechanisms. Recent structural data have provided insights into these mechanisms, extending our understanding of E3 function and regulation.

    • Lori Buetow
    •  & Danny T. Huang
  • Review Article |

    The role of epigenetic regulation in adult stem cell function depends on the specific tissue and factor, but it commonly affects stem cell maintenance, self-renewal and differentiation without disrupting germ-layer fate.

    • Alexandra Avgustinova
    •  & Salvador Aznar Benitah
  • Review Article |

    The DNA of mammalian cells can be damaged by various endogenous and exogenous insults, leading, if unrepaired, to genomic instability. Recently it has become apparent that bacterial pathogens can be a source of genomic instability, owing to their combined capacity to incur DNA damage and to interfere with DNA repair pathways.

    • Cindrilla Chumduri
    • , Rajendra Kumar Gurumurthy
    • , Rike Zietlow
    •  & Thomas F. Meyer