Volume 16 Issue 9, September 2015

Volume 16 Issue 9

'Microfluidic investigation' byVicky Summersby, inspired by the Review on p554.

Research Highlights


  • Review Article |

    DNA methylation and H3K9 methylation are typically associated with gene silencing. Genetic, genomic, structural and biochemical data reveal functional connections between these two epigenetic marks. They also highlight how specialized protein domains that recognize the marks are essential for their establishment and maintenance at appropriate genomic loci.

    • Jiamu Du
    • , Lianna M. Johnson
    • , Steven E. Jacobsen
    •  & Dinshaw J. Patel
  • Review Article |

    Measurement of protein binding to a large number of RNA variants reveals binding patterns and helps to quantify binding specificities, which enables the development of RNA–protein interaction models. Such models are changing the binary view of RNA binding by proteins as either specific or nonspecific.

    • Eckhard Jankowsky
    •  & Michael E. Harris
  • Review Article |

    The recent discovery of the genes encoding components of the mitochondrial calcium uniporter paves the way for further study of its mechanism of action and its relevance to physiological and pathological processes.

    • Kimberli J. Kamer
    •  & Vamsi K. Mootha
  • Review Article |

    The unique physical and chemical properties of microfluidic devices have underpinned notable recent advances in molecular cell biology research and will facilitate a new era of biological enquiry of increased precision.

    • Todd A. Duncombe
    • , Augusto M. Tentori
    •  & Amy E. Herr



  • Innovation |

    DNA assembly methods are essential to the field of synthetic biology. Casini et al. discuss the powerful DNA assembly methods and standards developed in the past decade that facilitate the streamlined assembly of genetic networks and even of whole chromosomes and cells.

    • Arturo Casini
    • , Marko Storch
    • , Geoffrey S. Baldwin
    •  & Tom Ellis