Volume 16 Issue 12, December 2015

Volume 16 Issue 12

'Folding with sugars' by Vicky Summersby, inspired by the Review on p742.

Research Highlights

Progress

  • Progress |

    Recent studies have changed our understanding of the prevalence and biological significance of DNA N6-adenine methylation (6mA) in eukaryotes. This modification is involved in regulating transcription, transposable elements and epigenetic inheritance, and thus can be considered to be a eukaryotic epigenetic mark.

    • Guan-Zheng Luo
    • , Mario Andres Blanco
    • , Eric Lieberman Greer
    • , Chuan He
    •  & Yang Shi

Reviews

  • Review Article |

    Microtubule plus ends and minus ends accumulate specific sets of proteins that can regulate microtubule dynamics, connect microtubules to cellular structures and recruit signalling molecules that collectively control cellular behaviour. Our knowledge of the factors that associate with microtubule ends, and the mechanisms through which they do this, has strongly increased in recent years.

    • Anna Akhmanova
    •  & Michel O. Steinmetz
  • Review Article |

    Plant genomes encode diverse small RNAs, such as microRNAs, secondary siRNAs, heterochromatic siRNAs and various RNA-dependent RNA polymerases, DICER proteins and ARGONAUTE proteins. Together, these constitute several genetic and epigenetic silencing pathways with diverse cellular and developmental functions, in processes including reproductive transitions, genomic imprinting and paramutation.

    • Filipe Borges
    •  & Robert A. Martienssen
  • Review Article |

    Membrane and soluble secretory proteins are glycosylated in the endoplasmic reticulum. The addition of N-linked glycans is important for protein folding and quality control, whereas O-linked mannoses have distinct functions in protein quality control. Recent studies have revealed the complexity of these glycan-directed modifications in protein biogenesis and degradation.

    • Chengchao Xu
    •  & Davis T. W. Ng

Perspectives

    Innovation

  • Innovation |

    Lipids tailor membrane identities and function as molecular hubs in all cellular processes. The development of pioneering technologies, including affinity-purification lipidomics and the liposome microarray-based assay (LiMA), will enable researchers to decipher protein–lipid interactions and enhance our understanding of how lipids modulate protein function and structure.

    • Antoine-Emmanuel Saliba
    • , Ivana Vonkova
    •  & Anne-Claude Gavin