Volume 15 Issue 1, January 2014

Volume 15 Issue 1

'Cell Death and Autophagy' by Vicky Summersby, inspired by this article series on Cell Death and Autophagy

Research Highlights


  • Review Article |

    The function of 53BP1 in DNA double-strand break repair is multifaceted, and includes mediator and effector roles. New appreciation of how it is recruited to damaged chromatin, and how it exerts control on pathway choice, has cemented the central role of 53BP1 in genome stability maintenance.

    • Stephanie Panier
    •  & Simon J. Boulton


  • Review Article |

    Renewal and repair of the intestinal epithelium depend on small populations of intestinal stem cells. Specific markers for these stem cells have recently been discovered. This advance, together with the development of new technologies to track endogenous stem cell activity and to generate new epithelia ex vivo, is shedding light on the mechanisms underlying intestinal stem cell-driven homeostasis and regeneration.

    • Nick Barker
  • Review Article |

    The mechanisms that drive cell intercalation and thereby cell rearrangements during morphogenesis vary in different developmental contexts and species. Comparison of the key control steps in each case has improved our understanding of the specific parts played by adhesion and cytoskeletal changes, as well as planar cell polarity signalling.

    • Elise Walck-Shannon
    •  & Jeff Hardin
  • Review Article |

    Interactions on the mitochondrial outer membrane between members of the three subgroups of the BCL-2 protein family set the apoptotic threshold. Recent structural insights into the molecular mechanisms of this commitment to apoptosis are guiding the development of new therapeutics for cancer, and potentially also autoimmune and infectious diseases.

    • Peter E. Czabotar
    • , Guillaume Lessene
    • , Andreas Strasser
    •  & Jerry M. Adams