News & Comment

A dual-activity complex of Integrator and protein phosphatase 2A dephosphorylates RNA polymerase II and suppresses transcription.

Ahmet Yildiz draws our attention to work on understanding the regulation of microtubule-based motors.

Daniloski, Jordan et al. report a genome-wide CRISPR–Cas9-mediated loss-of-function screen to identify host factors required for SARS-CoV-2 viral infection.

Wilfling et al. report a previously undescribed selective autophagy pathway that removes aberrant intermediates of clathrin-mediated endocytosis.

This poster highlights the derivation and differentiation of human pluripotent stem cells and outlines key applications of these cells, such as cell-based therapies, disease modelling, drug discovery and the study of human development.

Giancarlo Abis recounts his inspiration for becoming a structural biologist — the publication of the HIV-1 RT structure, which enabled a therapeutic breakthrough.

RNA editing by ADAR1 destabilizes epigenetic-treatment-induced retrotransposon stem–loops and thus dampens the immune response to the treatment, suggesting that ADAR1 could be a therapeutic target in combination with epigenetic therapy.

Sheng-Cai Lin discusses discoveries implicating glycolytic enzyme, aldolase, in glucose sensing.

The discovery of the CRISPR–Cas9 system by Emmanuelle Charpentier and Jennifer Doudna awarded a 2020 Nobel Prize in Chemistry.

A signalling pathway comprising TMO5–LHW and cytokinin controls plant adaptation to low-phosphate levels in the soil by increasing root hair density.

Wozniak and colleagues reveal that cleavage of the lysosomal protein RILP following activation of the inflammasome enhances exosome release and regulates the trafficking of miRNAs into exosomes by FMR1.

The switch from glycolytic metabolism to OXPHOS functions as a driver of cell immortalization during tumorigenesis in the fly brain.

We reflect on the position of Nature Reviews Molecular Cell Biology, 20 years from its launch.

Rafael Luna uses his own experiences to illustrate the power of storytelling as a tool to share your science and advance your career.

The role of chromosome clustering as a driver of nucleo-cytoplasmic compartmentalization after mitosis.

A 2017 paper showed that phase separation and formation of elastin in the extracellular matrix does not require protein secondary structures, but cross-linked disordered chains.

Gavin Kelsey discusses the first reports of genomic imprinting in mammals and how they raised the profile of epigenetics in the study of mammalian development.

Sally Lowell discusses the concept of ‘community effect’ when cells commit to a certain differentiation path, which was proposed by John Gurdon in 1988 and recently suggested to enable cancer cells to gain control.

Twenty years ago it was reported that epithelial–mesenchymal transition (EMT), a key developmental process, occurs in cancer; many studies have since, and still are, studying EMT heterogeneity and its functional implications.

Although the organization of cell membranes into lipid rafts has become a key concept in cell biology, how partitioning of membrane components into subdomains is achieved remains an important question.