News & Comment

OSKM-mediated reprogramming to pluripotencyin vivois facilitated by cellular senescence through the secretion of key cytokines.

A chemical approach for precisely mapping nucleosomes genome-wide provides novel insights into the regulation of transcription and splicing.

The newly identified SND pathway is an alternative route for the targeting of proteins to the endoplasmic reticulum that functions in parallel to the SRP and GET pathways.

The functional behaviour of haematopoietic stem cells is determined in a cell-autonomous manner by clone-specific epigenetic modifications.

Cadherin-based, finger-like cell–cell contacts are shown to serve as instructive structural cues that coordinate motility during collective cell migration.

Edith Heard describes how the discovery of lamina-associated domains changed her thinking about the mechanisms of X-chromosome inactivation and gene regulation.

Super-enhancers interact with human nucleoporins at the nuclear pore complex to regulate cell type-specific genes.

Job Dekker asserts that cases in which data from microscopy- and 3C-based methods appear discordant about genome organization will provide opportunities to improve our models of chromatin folding.

The activity of the plant photoreceptor cryptochrome 2 is regulated by a newly characterized interacting protein that prevents cryptochrome 2 homodimerization.

Selective autophagy that is dependent on the ER translocon component SEC62 mediates ER recovery following protein stress.

Physically bridging an enhancer to a β-globin gene increased transcription and explained how enhancers could function over long distances.

Genomic duplications that modify the structure and function of topologically associated domains can deregulate gene expression and cause disease without altering gene copy numbers.

Cyclin A2 ensures accurate chromosome segregation through cyclin-dependent kinase (CDK) activation, and proper DNA replication and repair through previously uncharacterized kinase-independent RNA-binding activity.

Elucidation of the mechanisms of autophagy and the work on designing molecular machines have been awarded with a 2016 Nobel Prize, in the fields of Physiology or Medicine and in Chemistry, respectively.