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In this Tools of the Trade article, Venkova and Popard (Piel lab) discuss recent updates to the fluorescence exclusion method that now enable simultaneous measurement of cellular and nuclear size as well as investigation of small prokaryotic cells.
In this Tools of the Trade article, Isomursu (Ivaska lab) describes a new method for dynamic micropatterning, which enables investigation of cell adhesion and migration on substrates that mimic different extracellular matrix environments.
In this Tools of the Trade article, Hugo Damstra and Josiah Passmore (Kapitein Lab) describe GelMap, which introduces a fluorescent reference grid into the workflow of expansion microscopy experiments, thus enabling a visual readout of sample deformation.
In this Tools of the Trade article, Khalid Ibrahim (Radenovic and Lashuel labs) describes a tool for the artificial intelligence (AI)-driven detection of cellular aggregates that bypasses the need for fluorescent labelling.
In this Tools of the Trade article, Lei Yuan (from the Cai lab) highlights a new culture system that allows in vitro reconstitution of a dynamic miniature mammary gland.
In this Tools of the Trade article, Yohan Lee (Stachowiak lab) describes a method to generate free-standing planar lipid membranes for the study of membrane-associated protein phase separation.
In this Tools of the Trade article, Manuela Richter (Dumont lab) describes a method to probe mechanisms of cytoskeletal network re-organization that uses a targeted laser to both trigger network remodelling and track network dynamics.
In this Tools of the Trade article, Bohan Zhang (Gladyshev lab) discusses how the use of extended heterochronic parabiosis in mice (surgical connection between circulatory systems for an extended period), followed by detachment, can shed light on potential mechanisms that reverse mammalian ageing.
In this Tools of the Trade article, Christine Lim and Alicia González Díaz (Vendruscolo lab) describe a pipeline for the identification and characterization of proteins whose phase separation is altered in disease.
In this Tools of the Trade article, Sarah Paramore (from the Devenport and Nelson labs) discusses the use of mouse strains carrying genomic alterations in PCP genes and how they can increase our understanding of mammalian planar cell polarity.
In this Tools of the Trade article, Joleen Cheah (from the Ting lab) discusses the development of TransitID, which allows researchers to capture protein trafficking pathways in vivo without a priori knowledge of specific proteins of interest.
In this Tools of the Trade article, Roffay and Mercier (from the Roux lab) describe the development of fluorescent Flipper probes that allow measurement of membrane mechanics in vivo.
In this Tools of the Trade article, William Leineweber (from the Fraley lab) describes the set-up of an integrated biophysical imaging platform that allows researchers to assess the interactions between cells and the surrounding extracellular matrix.
In this Tools of the Trade article, Edoardo José Longarini and Helen Dauben (from the Matić lab) describe the development and applications of mono-ADP-ribosylation antibodies and peptides.
In this Tools of the Trade article, Nouf Laqtom (at the Abu-Remaileh lab) describes the LysoIP system used to tag and isolate lysosomes for multi-omic approaches and to determine their composition under physiological and pathological states.
In this Tools of the Trade article, Benjamin Jackson (at the Finley lab) describes the use of genetic co-essentiality analysis to interrogate the assembly of metabolic networks, fuelling discovery of new aspects of metabolism.
In this Tools of the Trade article, Laura Capolupo (at D’Angelo lab) describes the approach to study cell-to-cell heterogeneity in lipid content and its correspondence to cell identity.
In this Tools of the Trade article, Patrik Risteski (at Tolić lab) describes high-throughput fluorescent speckle microscopy (FSM) based on a cell-permeable dye that allows to study dynamics of individual microtubules in human cells.
