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Keren Lasker discusses early work of Lucy Shapiro, which provided first evidence that bacterial cells spatially regulate their cellular processes, akin to their eukaryotic counterparts.
A long non-coding RNA is found to enable the assembly of a glycolytic metabolon that contributes to cell adaptation to metabolic stress and cell survival.
Olivier Voinnet proposes that movement of gene-silencing small RNAs (sRNAs) in plants can be regulated by intracellular sRNA biogenesis and activity factors expressed in silencing-signal emitting, traversed and recipient cells.
‘Alpha helix’ was not Linus Pauling’s first choice of a name for the protein structural motif. Egli and Zhang recount what the original name was, why it was changed and what is between the alpha helix and the DNA double helix.
Rana et al. show that in the gut epithelium, gasdermin B has an inherent, non-pyroptotic function, supporting the maintenance of the epithelial barrier when challenged with inflammatory damage.
Mike Henne discusses the pioneering work of Jean Vance, which revealed that mitochonodria-associated membranes (MAMs) are sites for inter-organelle phospholipid exchange and step-wise synthesis reactions.
Prior to introduction of the first DNA–protein structure, Ned Seeman et al. correctly conceived how proteins recognize specific sequences in double-helix nucleic acids.
