News & Comment

To mark the fiftieth anniversary of the European Molecular Biology Organization (EMBO), Gottfried Schatz reflects on the consequences of science growth, the challenges for young generations of researchers and on what EMBO has done for them.

Cyclin B1 and cyclin B2 regulate chromosome segregation through two distinct mechanisms.

PTENα is a novel PTEN isoform that interacts with PTEN to maintain mitochondrial structure and function.

Leu-rich repeat-containing protein 8A (LRRC8) is an essential component of the volume-regulated anion channel (VRAC).

Alfred Nordheim discusses how actin dynamics regulate the transcriptional activity of SRF.

The histone-fold protein Chrac14 controls chromatin mislocalization of CENPA and prevents aneuploidy after DNA damage.

The SREBP–mevalonate pathway promotes the activity of YAP and TAZ.

Two fungal Hook proteins are identified as recruiting motor proteins to early endosomes for microtubule-based transport.

The CSR-1 RNAi pathway activates transcription at a genome-wide level by controlling RNA polymerase II directionality.

A recent report inSciencedescribes the design and construction of an entire, engineered eukaryotic chromosome in yeast.

DNA double-strand breaks are not repaired during mitosis. Orthweinet al. now show that this is to prevent uncapped telomeres from fusing and causing aneuploidy.

The Polycomb protein Enhancer of zeste (E(z)) functions non-cell autonomously to maintain germ cell identity inDrosophila melanogaster.

The biogenesis of epigenetically activated siRNAs (easiRNAs) is triggered in plants by microRNAs to silence transposons.

The activation of the hexosamine biosynthetic pathway following endoplasmic reticulum stress promotes cell protection and longevity.

Thanos D. Halazonetis describes the discovery that break-induced replication is conservative in budding yeast.

Nuclear pore complexes bind the spindle assembly checkpoint protein MAD1 during interphase, which slows mitotic entry and lowers the threshold for mitotic arrest.