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A PRE/TRE is shown to alter gene expression by transcribing two mutually exclusive ncRNAs from opposing DNA strands in different tissues during development. The transcription activating ncRNA was shown to bind PcGin vivoand to inhibit its function.
Alternative splicing is responsible for generating a large ensemble of catalytically inactive aminoacyl-tRNA synthetases that have non-canonical functions.
Two studies report a novel membrane contact site between mitochondria and lysosome-like vacuoles in yeast, and reveal a physical and metabolic link between mitochondria and the endocytic compartment.
Michael Rape provides a striking example of how basic research — in this case in the plant sciences — can be unexpectedly informative for drug development.