News & Comment

Karl E. Kadler describes why the mechanism of collagen fibril assemblyin vivoremains elusive.

The ten-eleven-tanslocation (TET) family of proteins regulates enhancer methylation and activity in embryonic stem cells.

Angiogenic factors induce podosome rosettes in endothelial cells that mediate focal degradation of the basement membrane and blood vessel branching.

Fat cadherins are required for the function of the electron transport chain.

The Asi complex defines an ERAD branch that is specific for inner nuclear membrane protein quality control in yeast.

Using a system that offers high temporal resolution of transcription in single living cells, Stasevichet al. reveal that histone H3 Lys 27 acetylation enhances gene expression by promoting transcription elongation and transcription factor recruitment.

Kazutoshi Mori and Peter Walter were awarded the 2014 Albert Lasker Basic Medical Research Award for their discoveries on the unfolded protein response.

To achieve effective visual communication of complex data, it is important that biologists identify the needs of their audience — whether they are peers or an outreach audience. This guide to the available wealth of resources, ranging from software tools to professional illustrators, should help researchers to generate better figures and presentations tailored to the needs of any audience.

VLK is identified as the first extracellular Tyr kinase. It targets extracellular proteins and those in the secretory pathway.

PTEN maintains chromosome condensation by interacting with histone H1.

Lobopodial migration is driven by increased hydrostatic pressure in the cell anterior as a result of forward motion of the nucleus.

Andreas Strasser describes the first paper to outline a physiological role for apoptosis downstream of the death receptor FAS inlprmice.

RIPK1 can inhibit apoptosis and necroptosis through a kinase-independent scaffolding function, which is important for maintaining epithelial homeostasis.

The size reduction ofXenopus laevisnuclei during development is controlled by increased nuclear localization and activity of conventional protein kinase C (cPKC).

The substrate specificity of the histone Lys demethylase KDM2A was elucidated by solving its crystal structure in complex with methylated peptides. Follow-up structure-guided mutant analyses substantiated its roles in suppressing cellular transformation.