News & Comment

A signalling pathway comprising TMO5–LHW and cytokinin controls plant adaptation to low-phosphate levels in the soil by increasing root hair density.

Wozniak and colleagues reveal that cleavage of the lysosomal protein RILP following activation of the inflammasome enhances exosome release and regulates the trafficking of miRNAs into exosomes by FMR1.

The switch from glycolytic metabolism to OXPHOS functions as a driver of cell immortalization during tumorigenesis in the fly brain.

The role of chromosome clustering as a driver of nucleo-cytoplasmic compartmentalization after mitosis.

A new study demonstrates that glypicans shield the palmitoleate on WNTs to enable their distribution in tissues.

DPPA2 and DPPA4 maintain promoter bivalency and low levels of DNA methylation at certain lineage-specific genes.

Vietri et al. show that failure to repair micronuclear membranes is caused by unrestrained activity of ESCRT-III.

Extracellular vesicles secreted from cells of young donors ameliorate senescence-related damage in cells from old donors

Increased expression of the circular RNA generated by the sulfateless gene (circSfl), and of the protein it encodes, can extend the lifespan of flies.

Young and colleagues show that anti-cancer compounds can undergo partitioning into biomolecular condensates, affecting their activity.

A non-catalytic function of PRC1 is required for chromatin interactions that can facilitate developmental gene activation.

Premalignant skin stem cells become dependent on extracellular serine for proliferation, and this metabolic reprogramming inhibits tumour-suppressing cell differentiation.

Bass and colleagues uncover a role for NAD⁺ in preventing age-related decline in circadian function in mice.

A group of endogenous 22-nucleotide siRNAs, which is produced by Dicer-like 2 proteins, represses translation and contributes to plant adaptation to environmental stress.

Mitochondrial fission at plasma membrane wounds induces local signalling via mitochondria-derived reactive oxygen species for membrane repair.

The histone acetylation oncoprotein BRD4-NUT helps establish a nuclear subcompartment that supports high levels of gene expression.

A new study in Molecular Cell shows that human mitochondrial DNA is enriched for the DNA modification N⁶-methyldeoxyadenosine, which can repress mitochondrial gene expression and regulate the transcriptional response to mitochondrial stress.

Many ‘non-coding’ RNAs contain different types of coding sequences, which are translated into functional microproteins or peptides.

In their study in Cell Liang et al. identify 200 regulators of ER-phagy and specifically dissect the role of mitochondrial oxidative metabolism and protein UFMylation in promoting ER-phagy.

Tau post-translational modifications and their crosstalk contribute to the formation of disease-specific intracellular tau aggregates.