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Laurent Blanchoin reminds us of a seminal paper by Tom Pollard reporting the meticulous measurement of rate constants of actin assembly, and highlights its contribution to quantitative understanding of actin filament dynamics as well as its impact on his own research interests.
Mechanical strain, transmitted by the remodelling of the actomyosin cytoskeleton and concomitant depletion of the nuclear actin pool, is shown to induce silencing of differentiation genes in epidermal stem cells, linking mechanical cues to the genetic regulation of cell fate.
Proteins of the mitotic checkpoint regulate insulin receptor internalization through clathrin-mediated endocytosis, thereby modulating insulin signalling and systemic glucose metabolism.
The endonuclease CPS-6 mediates the degradation of paternal mitochondrial DNA and promotes paternal mitochondrial elimination through autophagy inCaenorhabditis elegans.
Whereas activation of p21 by p53 causes G1 cell cycle arrest, p53-independent expression of p21 can cause deregulation of DNA replication and genomic instability.
Hrd1 may form a channel regulated by autoubiquitylation that has a major role in translocating misfolded proteins from the ER lumen to the cytoplasm for subsequent degradation.
It turns out that Meselson and Stahl were not the first to show that DNA replicates semi-conservatively. The preceding experiment was almost forgotten, partly because it showed something incredible.
Four research groups have developed, independently, an imaging technique that enables us, for the first time, to track and study the translation of single mRNA molecules in living cells.
