News & Comment

Torrino et al. show that the stiffness of the extracellular matrix regulates microtubule posttranslational modification via glutamylation, which impacts microtubule dynamics and cell invasiveness.

Migrasomes function as a mitochondrial quality control mechanism in migrating cells, and affect neutrophil viability.

Nuclear condensates of m⁶A-methylated mRNAs with their ‘reader’ YTHDC1 prevent the degradation of acute myeloid leukaemia-promoting mRNAs by the exosome.

Dwivedi et al. now show that DNA replication stress is an important trigger for cell extrusion.

The histone reader PHF7 binds to cardiac super-enhancers and is a strong activator of the reprogramming of adult cardiac fibroblasts to induced cardiac-like myocytes.

The transcription factor p53 boosts the expression of a distinct subset of its target genes by enhancing their association with nuclear speckles.

Roney et al. show that neuronal loss in Niemann-Pick disease type C is associated with the impairment of lysosome trafficking by cholesterol that accumulates on lysosome membranes.

Unexpected high levels of recurrent DNA single-strand break repair were detected in enhancer regions of post-mitotic neurons.

Lancaster and colleagues describe a morphological change in early primate brain stem cells, the timing of which could underlie the differences in brain size between human and apes.

Moore et al. show the role of actin assemblies in regulating the balanced distribution of a healthy mitochondrial network between daughter cells in mitosis.

Cancer cells with supernumerary centrosomes have disrupted lysosomes, which enhances the secretion of exosomes that promote malignancy.

Aberrant activation of the innate immunity enzyme cGAS during mitosis is suppressed by hyper-phosphorylation and by chromatin tethering.

Hoijman et al. show that in early vertebrate development, engulfment of apoptotic cells is mediated by epithelial cells covering the embryo, which use specialized protrusions to distribute apoptotic bodies and support their efficient clearance.

Gadadhar et al. report that tubulin glycylation enables sustained motion of sperm by regulating the beating of sperm flagella.

Changes in RNA abundance in transcriptional condensates provide dynamic feedback on transcription.

Agudo-Canalejo et al. now report in Nature that the process of wetting, whereby a liquid establishes a contact with a surface, underlies interactions of phase-separated droplets with autophagic membranes.

mRNA translation is found to occur in cytosolic stress granules, membraneless organelles that form via liquid−liquid phase separation when cells are exposed to cell-intrinsic or environmental stress.

Embryonic stem cells are found to generate fibronectin-containing extracellular vesicles that inhibit differentiation and promote pluripotency.

A team led by the late Beth Levine discovered that viral xenophagy depends on sorting nexin 5.