Research Highlights in 2013

Ciliary calcium concentrations are controlled by the PKD1L1–PKD2L1 channel and modulate HH signalling.

FtsA has a dual role in FtsZ network assembly and rearrangement.

The role of E2F transcription factors in apoptosis depends on effects on mitochondrial function, as well as the transcription of pro-apoptotic genes.

YTHDF2 is a 'reader' protein that recognizes m⁶A-containing mRNAs and targets them for degradation.

Der1 ensures transit of misfolded substrates for ER-associated degradation.

RZZ interacts with NDC-80 to inhibit the formation of end-coupled microtubule attachments.

Lin28aenhances tissue repair by increasing oxidative metabolism.

The formation of diverse CBC subcomplexes determines RNA fate by connecting 3′ end formation, degradation and export.

The ERF115 transcriptional activator is a rate-limiting factor of quiescent centre cell division.

Mice lacking the mitochondrial calcium uniporter have an impaired ability for strenuous muscular work.

Shows how talin and Gα₁₃determine the direction of integrin signalling.

Mild mitochondrial stress prolongs longevity by inhibiting insulin signalling.

HSC ageing in mice depends on a switch from canonical to non-canonical WNT signalling.

Nuclear shape is regulated by dppa2-mediated control of microtubule assembly.

Asymmetric ciliary membrane inheritance leads to the asymmetric re-establishment of the cilium and ciliary signalling in daughter cells.

The commitment of a cell to proliferation or quiescence is determined at the end of the previous cell cycle and directly regulated by p21.

A reciprocal relationship between autophagy and ciliogenesis is revealed.

Cytoplasmic RNA granules control the timing of cyclin B1 translation in oocytes.

Specific nuclear pore complex proteins mediate processing of RNA polymerase III-generated transcripts.

JNK activation inhibits Warts and LATS to increase Yorkie and YAP activity.