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Cell division

Ciliary membrane inheritance directs ciliogenesis

Nature Reviews Molecular Cell Biology volume 14, pages 750–751 (2013)Cite this article

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the shortening cilium is internalized with the mother centriole prior to mitosis

The authors found that in mitotic mouse apical progenitor cells (which are epithelial neural stem cells), the GTPase ADP-ribosylation factor-like protein 13B (ARL13B; which marks the primary cilium membrane) localized to the mother centriole-containing centrosome throughout mitosis. Using electron microscopy, they showed that the centriole was attached to membranous structures. These structures corresponded to the ARL13B-positive puncta seen by light microscopy, which suggests that they were remnants of the ciliary membrane. In agreement with this idea, enhanced GFP-tagged ciliary membrane proteins were detected in close proximity to centrosomes in mitotic apical progenitor cells. Further work showed that centrosome-associated ARL13B-positive membrane is endocytosed from the cell surface at the onset of mitosis, and thus that the primary cilium is not completely disassembled prior to mitosis but instead that a ciliary remnant remains attached to the mother centriole.

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References

  1. Paridaen, J. T. M. L., Wilsch-Bräuninger, M. & Huttner, W. B. Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division. Cell 155, 333–344 (2013)

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  1. Andrea Du Toit
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Du Toit, A. Ciliary membrane inheritance directs ciliogenesis. Nat Rev Mol Cell Biol 14, 750–751 (2013). https://doi.org/10.1038/nrm3697

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