Browse Articles

  • Research Highlight |

    Glycoproteins of the glycocalyx are shown to have the capacity to bend the plasma membrane.

    • Paulina Strzyz
  • Research Highlight |

    Editing the protein sequence of the transcription factor SKN-1A/Nrf1 regulates its function and the expression of proteasome subunits.

    • Kim Baumann
  • Research Highlight |

    Glucose deprivation induces ER stress, which enhances mitochondrial respiration by promoting the assembly of respiratory supercomplexes.

    • Paulina Strzyz
  • Journal Club |

    Susana Godinho discusses a 1996 paper by Heald et al. on the organization of microtubules into bipolar spindles.

    • Susana A. Godinho
  • Review Article |

    Nonsense-mediated mRNA decay (NMD) is a quality and quantity control mechanism for degrading mutated mRNAs to protect the integrity of the transcriptome and proteome and unmutated mRNAs to control their quantity. NMD dysfunction in humans is associated with intellectual disability and cancer.

    • Tatsuaki Kurosaki
    • , Maximilian W. Popp
    •  & Lynne E. Maquat
  • Review Article |

    Cellular metabolism is rewired in proliferating cells to support their increased need for macromolecule biosynthesis. A better understanding of how cells utilize nutrients for biosynthetic pathways and how they overcome the metabolic challenges associated with high proliferation rates can lead to better control of cell proliferation and improved cancer treatments.

    • Jiajun Zhu
    •  & Craig B. Thompson
  • Journal Club |

    Jesús Gil discusses the first evidence for cellular senescence being associated with ageing, and how these studies opened new routes for basic and translational research.

    • Jesús Gil
  • Comment |

    Michael Levin and colleagues discuss the need to rethink how the causes of cell biological processes are being identified.

    • Mariano Bizzarri
    • , Douglas E. Brash
    • , James Briscoe
    • , Verônica A. Grieneisen
    • , Claudio D. Stern
    •  & Michael Levin
  • Review Article |

    Cilia, and primary cilia in particular, are important signalling organelles with established roles in odorant, light and Hedgehog morphogen signal transduction. Cilia are enriched in signalling receptors and effectors and in specific lipids. Addressing how this unique composition is established and maintained is key to understanding cell signalling.

    • Maxence V. Nachury
    •  & David U. Mick
  • Research Highlight |

    The serotonylation of histone H3 Gln5 promotes transcription of neuronal genes during neuronal cell differentiation, by potentiating the binding to promoters of the transcription factor TFIID.

    • Eytan Zlotorynski
  • Review Article |

    Components of the ribosome-associated protein quality control (RQC) pathway recognize truncated proteins resulting from the stalling of ribosomes on mRNAs during translation and target them for degradation. Defects in RQC can lead to disease, and recent insights have revealed RQC mechanisms in the cytosol and on mitochondria and the endoplasmic reticulum that involve the E3 ligase listerin and/or the formation of carboxy-terminal alanine and threonine tails.

    • Claudio A. P. Joazeiro
  • Research Highlight |

    A group of mesenchymal stem cell transcription factors promotes osteogenesis and represses adipogenesis.

    • Kim Baumann
  • Research Highlight |

    Two studies in Science show that biomolecular condensates of membrane-associated signalling complexes increase the residence of signalling effectors within these complexes.

    • Paulina Strzyz
  • Research Highlight |

    Two independent studies from Science report that hypoxia causes histone hypermethylation by direct modulation of histone lysine demethylases.

    • Paulina Strzyz
  • Journal Club |

    Channing Der and Kirsten Bryant discuss recent work leading towards therapeutic targeting of autophagy in pancreatic cancer.

    • Kirsten L. Bryant
    •  & Channing J. Der
  • Research Highlight |

    DNA replication of under-replicated loci can occur after mitosis in 53BP1-contaning nuclear bodies and is required for genome stability.

    • Anne Mirabella
  • Review Article |

    Genome organization can regulate gene expression, but can gene expression regulate genome organization? Recent studies reveal that, although not required for higher-level genome organization, transcription has a role in the formation and stabilization of genomic subdomains and enhancer–promoter interactions.

    • Bas van Steensel
    •  & Eileen E. M. Furlong
  • Research Highlight |

    Four studies provide new insights into the mechanism, functions and regulation of the cGAS–STING pathway.

    • Paulina Strzyz
  • Research Highlight |

    High-throughput FISH analysis reveals that chromatin interactions are highly variable between cells and between alleles in individual cells.

    • Eytan Zlotorynski
  • Review Article |

    Following DNA damage, the transcription factor p53 determines whether cells undergo apoptosis or cell cycle arrest and DNA repair. To enable different cellular outcomes, p53 is regulated through its temporal expression dynamics and post-translational modification, and by interactions with chromatin, chromatin regulators and transcription factors.

    • Antonina Hafner
    • , Martha L. Bulyk
    • , Ashwini Jambhekar
    •  & Galit Lahav
  • Review Article |

    Metabolites can actively regulate biological processes and may directly modulate phenotype. The current challenge of metabolomics is to provide a platform for the discovery of such bioactive metabolites and — in combination with other omics technologies — to determine their biological functions.

    • Markus M. Rinschen
    • , Julijana Ivanisevic
    • , Martin Giera
    •  & Gary Siuzdak
  • Research Highlight |

    Three studies provide new insights into the mechanisms responsible for genome remodelling and changes in gene expression associated with senescence.

    • Paulina Strzyz
  • Research Highlight |

    Lipin 1 and ARF1 control SREBP trafficking, processing and activity to regulate lipid synthesis in response to mechanical cues from the extracellular matrix.

    • Grant Otto
  • Review Article |

    The haematopoietic stem cell (HSC) niche in the bone marrow ensures haematopoiesis by regulating the function of HSCs and progenitor cells. An improved understanding of this regulation in homeostasis, ageing and cancer should aid the development of therapies to rejuvenate aged HSCs or niches and treat malignancies.

    • Sandra Pinho
    •  & Paul S. Frenette
  • Review Article |

    By opposing protein ubiquitylation, deubiquitylating enzymes (DUBs) regulate various cellular processes, including protein degradation, the DNA damage response, cell signalling and autophagy. Many DUBs show high specificity for ubiquitin chain architecture and/or the protein substrate that they recognize, and have emerged as exciting therapeutic targets within the field of proteostasis.

    • Michael J. Clague
    • , Sylvie Urbé
    •  & David Komander
  • Review Article |

    Misfolded proteins have a high propensity to form potentially toxic aggregates. Cells employ a complex network of processes, involving chaperones and proteolytic machineries that ensure proper protein folding and remodel or degrade misfolded species and aggregates. This proteostasis network declines with age, which can be linked to human degenerative diseases.

    • Mark S. Hipp
    • , Prasad Kasturi
    •  & F. Ulrich Hartl
  • Research Highlight |

    Cells can efficiently invade the tissue in the absence of metalloproteinases by physically breaching the basement membrane.

    • Paulina Strzyz
  • Research Highlight |

    Cells in telomere crisis undergo cell death through autophagy, which is triggered by chromosome breakage and transduced by the cGAS–STING pathway.

    • Eytan Zlotorynski
  • Research Highlight |

    Palmitoylation-driven partitioning of importin-α at the plasma membrane contributes to intracellular scaling.

    • Paulina Strzyz
  • Review Article |

    Spatial proteomics improves our understanding of protein function by revealing the subcellular localizations of proteins and their movement between compartments. This Review discusses spatial proteomics approaches, their successful application in cell biology and ways to improve integration of spatial proteomics data.

    • Emma Lundberg
    •  & Georg H. H. Borner
  • Review Article |

    BCL-2 family proteins are the mediators of apoptotic cell death. The balance between pro-apoptotic and pro-survival BCL-2 family members is differently regulated in various physiological contexts to modulate cellular apoptotic susceptibility. Perturbation of this balance causes excessive or insufficient cell death, leading to diseases such as neurodegeneration and cancer.

    • Rumani Singh
    • , Anthony Letai
    •  & Kristopher Sarosiek
  • Research Highlight |

    Single-cell allelic expression analysis reveals that enhancers predominantly modulate the frequency of transcription bursts whereas core promoters affect their size.

    • Grant Otto
  • Review Article |

    Circadian rhythms align organismal functions with phases of rest and activity. Accordingly, circadian oscillations occur in many physiological processes, including various metabolic functions. In turn, metabolic cues are emerging as regulators of the circadian clock. This crosstalk between metabolism and circadian rhythms has important implications for human health.

    • Hans Reinke
    •  & Gad Asher
  • Review Article |

    Recent functional and proteomic studies have revealed the remarkable complexity of mitochondrial protein organization and interactions. This Review discusses how the mitochondrial protein import machinery functions as a key organizer of these protein networks, its involvement in the formation of membrane contact sites, and how defects in protein import can lead to disease.

    • Nikolaus Pfanner
    • , Bettina Warscheid
    •  & Nils Wiedemann
  • Research Highlight |

    ORP2 is a lipid transfer protein that exchanges cholesterol for phosphatidylinositol-4,5-bisphosphate at the plasma membrane.

    • Grant Otto
  • Review Article |

    An increase in white adipose tissue is associated with obesity and reduced metabolic function. Interestingly, however, adipose tissue expansion through the generation of new adipocytes (adipogenesis), rather than through increasing adipocyte size, can prevent this metabolic decline. Thus, a better understanding of adipogenesis can inform new strategies to increase metabolic health in humans.

    • Alexandra L. Ghaben
    •  & Philipp E. Scherer
  • Research Highlight |

    A plant complex comprising SUVH1, SUVH3, DNAJ1 and DNAJ2 counteracts DNA-methylation-mediated silencing of transposon-neighbouring genes.

    • Eytan Zlotorynski
  • Research Highlight |

    Mitochondrial dynamics regulates stem cell expansion and differentiation.

    • Paulina Strzyz
  • Review Article |

    The Hippo pathway effectors YAP and TAZ regulate normal and tumorigenic organ growth. Recent studies in vitro and in mouse models have shown that these two transcription co-activators can also promote tissue regeneration. This property could be exploited for regenerative medicine, as long as the therapeutic approaches can minimize the potential for cancer development.

    • Iván M. Moya
    •  & Georg Halder
  • Research Highlight |

    STELLA protects the genome of mouse oocytes from de novo DNA methylation by the E3 ubiquitin ligase UHRF1 and the DNA methyltransferase DNMT1.

    • Kim Baumann
  • Review Article |

    Lipid droplets are storage organelles that are important for the regulation of lipid and energy homeostasis, and that serve as buffers against lipotoxicity. Recent studies on the biology of lipid droplets have led to new discoveries about their biogenesis and the complexity of their interactions with other organelles at membrane contact sites.

    • James A. Olzmann
    •  & Pedro Carvalho
  • Research Highlight |

    DNA N6-adenosine methylation is a transgenerational epigenetic modification that confers mitochondrial stress adaptation in the nematode Caenorhabditis elegans.

    • Grant Otto
  • Journal Club |

    David Barford discusses how the template model for MAD2 activation in the spindle assembly checkpoint represented a new concept for generating and propagating intracellular signals.

    • David Barford