Research Highlights

Age-dependent increase in CXCL13 production by hepatic macrophages contributes to HBV clearance in adults.

The skin and intestines of teleost fish show similar immunological adaptations.

γδ T cells in the intestinal tissues can provide long-lasting memory responses.

TSLP and basophils collaborate to cause food allergy.

Enhanced TGFβ receptor signalling may predispose individuals to a range of allergic diseases by skewing regulatory T cell activity.

T_Regcell homeostasis relies on the tight control of apoptosis.

Lengthening of the cell cycle by high PU.1 levels sustains a stable myeloid cell fate.

Treatment with a mixture of 17 Clostridia strains or with short-chain fatty acids promotes colonic T_Regcell function.

Ethnic variation shapes inflammatory responses during cholera and tuberculosis infections.

SHP1 negatively regulates IL-4R signalling to control the population expansion of memory-phenotype T cells.

NKG2D-mediated cytotoxicity of NK cells and CTLs is regulated by intracellular free Mg²⁺concentration.

Harmful B cell responses are eliminated using inhibitory liposomes.

An unrestrained innate inflammatory response driven by pro-inflammatory neutrophils underlies lethal influenza virus infection.

IFNα-induced exosomes transfer antiviral mediators to surrounding cells.

Omega 3 fatty acids negatively regulate inflammasome activation through a G protein-coupled receptor pathway.

IL-20R signalling inhibits pro-IL-1β expression and underlies susceptibility to infection withStaphylococcus aureus.

Autophagy is an epithelial cell-intrinsic innate immune mechanism that protects against the dissemination of invasive intestinal bacteria.

Ubiquitylation of MHC class II molecules by DC-expressed MARCH1 is required for thymic T_Regcell development.

Neutrophil clearance controls the circadian release of haematopoietic progenitor cells from the bone marrow in the steady state.

The switch to aerobic glycolysis in activated CD4⁺T cells is required for full effector function but not for proliferation or survival.