Volume 16 Issue 9, September 2019

Telephone or web-based psychotherapy has been suggested to be as effective as face-to-face psychotherapy while lowering access restrictions and improving patient acceptability. A large new study in patients with IBS shows the superiority of such an approach in comparison with treatment as usual.

Nonalcoholic fatty liver disease (NAFLD) has become the most common form of chronic liver disease in children and adolescents. In this Review, the authors summarize current knowledge and new advances related to the epidemiology, pathogenesis and management of paediatric NAFLD.

Macrophages are the gatekeepers of intestinal immune homeostasis. This Review discusses the molecular and cellular mechanisms involved in the differentiation and function of intestinal macrophages in homeostasis and inflammation, and their role in resolving the inflammatory process.

Telomerase is a key enzyme for cell survival that prevents telomere shortening. In this Review, the roles of telomeres and telomerase in cirrhosis and liver carcinogenesis are discussed, in addition to their potential in clinical practice as biomarkers and therapeutic targets.

This Consensus Statement provides a conceptual and methodological framework to expand research on colonic motility in experimental animals and humans. The work is intended to facilitate the development of new drugs for common colonic motility disorders and of appropriate diagnostic and therapeutic algorithms for the management of paediatric and adult patients.