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Volume 16 Issue 3, March 2019

Reviews on macrophages in NAFLD and NASH, PGC1s in liver metabolism and pathogenesis, pancreatitis epidemiology and prevention, IL-12, IL-23 and IL-17 in IBD, and commentaries on cell-based therapy for Crohn’s disease and trial end points in primary sclerosing cholangitis.

Mouse small bowel myenteric neurons, nerve fibres and muscularis macrophages that control motility, visualized by immunohistochemistry and provided by S. Huerta López and M. Avetisyan, Heuckeroth Group, Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, USA. Cover design: Laura Marshall.

Volume 16 Issue 3

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Comment

  • Cell-based therapies for the treatment of perianal Crohn’s disease have well-established safety profiles and improved efficacy compared with conventional therapy. However, stem cells are not a homogeneous product and questions remain before we can optimize clinical trials of these treatments and achieve best patient outcomes.

    • Amy L. Lightner
    Comment

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Research Highlights

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News & Views

  • A new study of a fibroblast growth factor 19 analogue in patients with primary sclerosing cholangitis (PSC) provides provocative results. The data challenge alkaline phosphatase levels as the appropriate surrogate end point in PSC trials and highlight alternatives, urging efforts to identify better clinical end points for this disease.

    • Alessio Gerussi
    • Pietro Invernizzi
    News & Views
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Reviews

  • The liver is a key metabolic organ, and alterations to hepatic metabolism are important for the development of disease. In this Review, the authors explore the central roles of peroxisome proliferator-activated receptor-γ coactivators (PGC1s) in physiological and pathophysiological settings, with a focus on nonalcoholic fatty liver disease and liver cancer.

    • Elena Piccinin
    • Gaetano Villani
    • Antonio Moschetta

    Series:

    Review Article

  • In this Review, Yadav and Petrov discuss the most up-to-date epidemiological data on acute and chronic pancreatitis. The authors also present strategies to reduce the burden of pancreatitis and its associated metabolic disorders.

    • Maxim S. Petrov
    • Dhiraj Yadav
    Review Article

  • This Review outlines the current understanding of IL-12 and IL-23 biology in IBD, as well as the roles of major downstream cytokines, including IL-17. The authors also discuss how emerging knowledge influences the development of therapeutic strategies in IBD.

    • Alexander R. Moschen
    • Herbert Tilg
    • Tim Raine
    Review Article
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