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Hepatocellular carcinoma in 2011

Genomics in hepatocellular carcinoma—a big step forward

Nature Reviews Gastroenterology & Hepatology volume 9, pages 69–70 (2012)Cite this article

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Despite enthusiastic efforts using the latest advanced molecular technologies, no specific universal genetic alteration has been found in hepatocellular carcinoma (HCC). The application of whole-genome sequencing using next-generation sequencing technologies is starting to clarify the intraindividual and intratumoral diversity in genomic alterations in HCC. A new sequencing era in HCC has begun.

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Figure 1: Whole-genome view of somatically acquired alterations in the liver cancer genome.

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Acknowledgements

The authors appreciate the advice given by Dr. Yoshinari Asaoka in preparing the manuscript.

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Authors and Affiliations

  1. Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan

    Ryosuke Tateishi

  2. Yamanashi Prefectural Hospital Organization, 1-1-1, Fujimi, Kofu-shi, 400-8506, Yamanashi-ken, Japan

    Masao Omata

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  1. Ryosuke Tateishi
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  2. Masao Omata
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Correspondence to Masao Omata.

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The authors declare no competing financial interests.

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Tateishi, R., Omata, M. Genomics in hepatocellular carcinoma—a big step forward. Nat Rev Gastroenterol Hepatol 9, 69–70 (2012). https://doi.org/10.1038/nrgastro.2011.255

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