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A study in Cell describes how non-coding RNAs can drive the formation of higher-order RNA-chromatin structures in the nucleus, with a role in mediating chromatin conformation and gene expression.
Tom Misteli highlights a 2006 study by Shopland et al., which used relatively simple methods to visualize characteristics of chromosome organization. Their conclusions foreshadowed key concepts in the field: topologically associating domains, compartments and cell-to-cell heterogeneity in genome organization.
In this Journal Club article, Fowzan Alkuraya describes how a paper outlining the mathematical foundations of homozygosity mapping provided a route to disease gene identification that still benefits his patients in clinical practice today.
A study in Nature Communications shows that horizontal transfer of bacterial chromosomes by phage-mediated lateral transduction renders them more mobile than many classically defined mobile genetic elements, including plasmids and transposons.
In this Review, Ethan Bier discusses how several impactful technical advancements, particularly involving CRISPR-based methods, are providing a diverse toolkit of gene-drive systems for the control of populations such as insect vectors of disease.
The evolutionary persistence of animal symbioses depends on both host and symbiont innovations. Perreau and Moran review how genome sequencing and related experiments have clarified how these innovations arise under different symbiont population structures, categorized here as open, closed and mixed.
Regular physical activity reduces the risk of chronic disease and mortality, but the mechanisms underpinning this protective effect are poorly understood. Here, Kim et al. review candidate genes and pathways implicated in human performance by genetic, genomic and multi-omic studies.
The authors review intra-individual and inter-individual plant epigenome variation during development and in response to environmental changes, including stress. They also discuss functions of epigenome plasticity and epigenome editing technologies that will drive future research.
