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A new study in Science reports a synthetic biology approach to encode an ultrasound-based gene expression reporter that is applicable to mammalian cells in vitro and in vivo.
A new study in Cell reports that sense-strand Piwi-interacting RNAs have an important role in protecting the germline genome from invading retroviruses.
A study in Nature retraces the convergent evolution of resistance to cardiac glycosides in insects, pinpointing the adaptive alleles and their functional consequences.
This Review provides an overview of different approaches for measuring nascent RNA synthesis. It discusses the complementary strengths of these different methods and how they have contributed to a mechanistic understanding of transcription regulation.
The interactions between tumours and the immune system are highly complex. This article discusses methods — primarily computational tools — for characterizing diverse aspects of cancer–immune cell interactions, including antigen presentation, T cell repertoires and heterogeneity in cell types and cell states. The Review particularly highlights the insights from single-cell data from both sequencing technologies and in situ imaging of tissues.
The increased adoption of DNA sequencing in genetic association studies is uncovering a wide range of population genetic variation, including rare genetic variants. Although this rarity limits the statistical power of associating individual rare variants with phenotypes, this Review discusses the diverse methods for leveraging the collective effects of rare variants in order to uncover important roles in complex traits, particularly human diseases.
Whole-genome sequencing efforts have driven our understanding of transposable elements as a source of genetic variation and the focus is now shifting to understanding their expression and regulation. This Review summarizes the possible functional consequences of transposable element insertion and retention in the genome over time, with a focus on how mobile elements cause disease.
