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A new study in Cell reports a mammalian genetic screening strategy that combines CRISPR libraries with in situ sequencing to read out both complex cellular phenotypes and genetic perturbations using microscopy.
In a new study published in Nature, Kanton et al. shed light on the unique genetic features of human forebrain development and how they diverged from those in great apes.
Mohammadi et al. report the development of ANEVA–ANEVA-DOT, a statistical model that quantifies variation in gene dosage, and demonstrate its potential for identifying genes harbouring rare pathogenic variants.
A new genome editing strategy called prime editing uses a catalytically impaired Cas9 fused to an engineered reverse transcriptase to write desired genetic sequence information directly into a target locus.
Two studies in Nature Genetics provide high-resolution maps of genetic variation across melon and watermelon species, respectively, and identify candidate loci linked to fruit quality traits through genome-wide association studies and population genomic analyses.
A new study provides the largest whole-genome sequence data set in an African population to date and shows that genetic causes of disease might be different in African and European populations.
This Review discusses the potential of DNA for creating machines that are both encoded by and built from DNA molecules. Alongside an overview of DNA nanostructure assembly, the authors describe recent advances and the remaining challenges, highlighting applications of custom DNA nanostructures as scientific tools.
This Review summarizes our current understanding of the molecular, genetic and epigenetic regulation of normal placentation, largely based on insights from the mouse model, and outlines the new opportunities provided by recent successes in deriving human trophoblast stem cells.
Aneuploidy contributes to tumorigenesis, but the underlying processes are not well understood. This Review explains the context dependency of aneuploidy in cancer and discusses its clinical potential as a prognostic marker and a therapeutic target.
