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  • Series |

    This series highlights the breadth of next–generation sequencing applications and the importance of the insights that are being gained through these methods.

  • Series |

    The scale and complexity of genetic and genomic data are ever-expanding, requiring biologists to apply increasingly more sophisticated computational tools in the analysis, interpretation and storage of these data. This series contains articles that focus on the application of these software tools in genetics and genomics.

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    Genetics continues to play a crucial part in furthering our understanding of the basis of disease, from revealing biological pathways involved in pathogenesis to improving knowledge of the relative contributions of various genetic and environmental factors. The articles in this series focus on genetic studies of specific diseases or specific processes in pathogenesis.

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    The articles in this series discuss insights into chromatin biology and the components and mechanisms of diverse epigenetic processes in health and disease.

  • Series |

    An abundance of data and unprecedented computational power are allowing sophisticated biological models to be devised and tested. This series of articles examines how the coupling of genetics with disciplines such as engineering, statistics, physics and computational biology has enriched our understanding in areas that range from developmental patterning to genetic association analyses.

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    The articles in this series consider the range of levels at which transcription is controlled, the molecules involved and how the modes of regulation are adapted to particular types of gene or developmental contexts.

  • Series |

    With improved methods to explore the transcriptome, in recent years there have been great advances in identifying and understanding non-coding RNAs. Regulatory pathways involving small RNAs, such as microRNAs, are now being elucidated in detail, and functions for long non-coding RNAs are also coming to light. The articles in this series discuss insights into the biology of non-coding RNAs of all sizes in a wide range of organisms.

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    The articles in this series discuss recent views on regulatory elements, including their role in evolution and the function of chromatin modifications, as well as methods to study these important regions of the genome.

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    The articles in this series provide detailed advice on the most appropriate and up-to-date means for designing experiments, with the aim of helping researchers to maximise the value of their data.

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    The articles in this series document the many ways in which genetic knowledge is changing medical practice, by facilitating screening tests, by informing diagnoses and drug prescribing and, perhaps before long, by routinely offering personalized health-risk assessments and tailored treatments.

  • Series |

    In the past 2 years genome-wide association studies in humans have revealed dozens of disease-associated loci and have provided insights into the allelic architecture of complex traits. Along the way, much has been learned about how best to carry out such studies. The articles in this series examine these design issues and the technical challenges that remain; for example, identifying association signals and interpreting the molecular mechanisms by which they exert their biological functions.

  • Series |

    This is a series of articles that celebrates the art and design of genetic screens. These reviews are intended to provide an up-to-date account of genetic screening in the main genetic experimental systems.