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Polycomb group (PcG) proteins have long been known to have repressive functions. Recently, novel complexes of PcG proteins have been identified and have been shown to have novel molecular and biological functions, which are discussed in this Review.
Network analyses of protein–protein, genetic and drug–gene interactions have typically been limited to analyses at the whole-protein and whole-gene levels. This Review discusses how high-resolution network analyses at the domain and residue levels are providing valuable insights into diverse research fields that range from structural biology to human disease.
This Review describes how whole-genome sequencing of experimental populations of microorganisms and other species is yielding new insights into evolutionary processes. These details include variation in mutation rates, diverse genetic routes to adaptation and dynamic interactions within and between populations.