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A new study in Nature Methods describes a computational method named UTAG (unsupervised discovery of tissue architecture with graphs) that aims to identify and quantify higher-level tissue domains from biological images without previous knowledge.
A new paper in Science reports that human genomes encode a large repertoire of retroviral envelope-derived proteins, with potential roles in protecting from infection by other retroviruses.
A microscopy-based pooled CRISPR screening approach described in Cell enables the cellular functions of thousands of genes to be assessed at remarkable phenotypic depth.
A new study in Science reports the refactoring of genetic codes in Escherichia coli to create a bidirectional ‘genetic firewall’ that prevents genetic transfer from or to synthetic organisms.
A new study reports Epigenomic MERFISH, an imaging method that combines CUT&Tag and MERFISH to interrogate histone marks representing cis-regulatory elements in single cells while preserving spatial information.
A new study in Cell describes how topologically associating domains (TADs) of chromosomes can restructure to resolve the regulatory conflict that arises when a new gene incorporates into an ancestral TAD.
Jagadeesh, Dey et al. report the development of ‘sc-linker’, an open-source framework that integrates scRNA-seq and GWAS data to identify disease-associated cell types and processes.
A paper in Cancer Cell reports genetic ancestry-associated differences in clinical outcomes when using tumour mutational burden as a biomarker in the context of immune checkpoint inhibitor therapy.
A paper in Molecular Cell reports the characterization of a second functional light strand promoter (LSP2) in the mitochondrial genome, challenging the view that mitochondrial DNA replication and gene expression are coupled by their reliance on a single light strand promoter (LSP).
Four papers in Science use single-cell, single-nucleus and spatial transcriptomic profiling of reptilian and amphibian brain tissue to provide insights into the evolution of vertebrate forebrains.
By studying the closest extant unicellular relatives of animals and fungi, a study in Nature contrasts the evolutionary trajectories leading to the origin of these groups.
Cooper et al. report in Science the use of massively parallel reporter assays and CRISPR-based validation to characterize the function of noncoding variants in dementia.
A new study in Cell has characterized genome-wide dosage sensitivity for 54 human disorders, providing insight into the causal genes and disease mechanisms associated with rare copy-number variants.
A study in Nature describes ‘DNA Typewriter’, a prime-editing-based DNA recording technology that can capture the order of large numbers of distinct molecular events in mammalian cells.
Two recent studies report microbial genome and gene catalogues that archive oceanic and glacial genomic and functional diversity at scale and yield insights into their biosynthetic potential.
A report in Cell takes single-cell CRISPR screens to genome scale and demonstrates how the transcriptional phenotypes can be used to resolve gene functions.
Gegenhuber et al. now show that, in mice, a neonatal surge in oestradiol activates oestrogen receptor-α to drive a sustained male-typical gene expression programme that determines brain sexual differentiation.
