Perspectives in 2021

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  • Studies have shown that the three pathways of regulated necrosis, namely necroptosis, pyroptosis and ferroptosis, can be therapeutically targeted. This Perspective summarizes existing data on the newly characterized cell death pathways in endocrine disorders.

    • Wulf Tonnus
    • Alexia Belavgeni
    • Andreas Linkermann
    Perspective
  • Understanding mineralized tissues, such as bone and cartilage, in health and disease requires a thorough knowledge of their structures. This Perspective proposes a new imaging and characterization strategy for mineralized tissue research that utilizes focused ion beam-scanning electron microscopy.

    • Steve Weiner
    • Emeline Raguin
    • Ron Shahar
    Perspective
  • As we approach the 30th anniversary of the 1991 Wingspread Conference on endocrine disruption, this Perspective addresses some historical points regarding the advent of the endocrine disruption field and the conceptual changes that endocrine disruption brought about.

    • Ana M. Soto
    • Cheryl M. Schaeberle
    • Carlos Sonnenschein
    Perspective