Reviews & Analysis

This PrimeView highlights the mechanisms underlying follicular lymphoma, a malignancy of germinal centre B cells.

Follicular lymphoma is an indolent malignancy composed of transformed follicular germinal centre B cells. In this Primer, Carbone and colleagues discuss the epidemiology, mechanisms and the recent developments in the treatment of this disease.

Diphtheria is an infectious disease caused by toxigenic strains of Corynebacterium diphtheriae. The molecular and geographical epidemiology of the bacteria is constantly evolving and, together with decreased vaccination coverage, could promote the re-emergence of this disease.

Diphtheria is a respiratory infection typically caused by toxigenic Corynebacterium diphtheriae strains; it prevalently affects children and can be fatal. Diphtheria can by effectively prevented by vaccination, but decreasing levels of vaccine coverage in several countries are promoting the resurgence of the disease.

Gonorrhoea is a sexually transmitted infection caused by the bacterium Neisseria gonorrhoeae and a major global public health concern. Tackling the disease burden requires a multidisciplinary approach including epidemiology, pathophysiology, diagnosis, prevention and management.

Gonorrhoea is a sexually transmitted infection caused by the bacterium Neisseria gonorrhoeae that affects millions of people worldwide, and its incidence is increasing in many settings. The emergence and spread of antimicrobial resistance in N. gonorrhoeae threatens to leave affected individuals with no effective treatments.

This PrimeView highlights the management strategies for bronchopulmonary dysplasia, a form of chronic lung dysfunction that results from lung and airway injury caused by respiratory support measures in (predominantly premature) newborn babies.

This Primer by Thébaud and colleagues discusses the epidemiology, mechanisms, diagnosis and treatment of bronchopulmonary dysplasia, a type of lung disease that can occur in preterm infants.

This PrimeView highlights the quality of life concerns that patients with craniopharyngiomas — embryonic tumours that arise along the craniopharyngeal duct in the skull — face.

Craniopharyngiomas are rare malformational intracranial tumours that arise along the craniopharyngeal duct. This Primer describes their formation, diagnosis and treatment, distinguishing between the two histological subtypes — adamantinomatous craniopharyngioma and papillary craniopharyngioma.

The main focus of this PrimeView is the prevention of suicide, which includes universal, indicated and selective interventions. This PrimeView accompanies the Primer article on Suicide and Suicide risk by Turecki et al.

Suicide and suicidal behaviour continue to present key challenges for public policy and health services. This Primer discusses the global burden of suicide and suicidal behaviours, and provides an overview of our current understanding of the mechanisms of suicide, including risk factors for suicidal ideation and the transition from ideation to suicide attempt.

This PrimeView accompanies the Primer on Ischaemic stroke by Campbell and colleagues and focuses on the mechanisms of ischaemic stroke.

Stroke is the second leading cause of death worldwide, and ischaemic stroke accounts for 71% of cases. This Primer by Campbell and colleagues discusses the epidemiology, mechanisms, diagnosis, prevention and treatment of ischaemic stroke.

Gout is a chronic disease of monosodium urate crystal deposition, usually presenting as an acute inflammatory arthritis in response to deposited crystals. This PrimeView highlights evolving approaches to management of gout.

Gout is a chronic form of arthritis caused by an inflammatory response to deposited monosodium urate crystals. This Primer discusses the epidemiology and pathogenesis of gout and evolving approaches for management of the disease.

This PrimeView highlights the management of breast cancer, the most frequent malignancy in women.

Breast cancer is the most frequent malignancy in women worldwide. Patients are managed on the basis of the key molecular and histological features underpinning their disease and its stage. This Primer discusses these issues, covering both early and advanced disease.

Fanconi anaemia, ataxia telangiectasia, Nijmegen breakage syndrome and Bloom syndrome are rare, clinically distinct, chromosome instability disorders that predispose to cancer. This PrimeView highlights the clinical features of these disorders, which are clinically distinct and affect quality of life.

Fanconi anaemia, ataxia telangiectasia, Nijmegen breakage syndrome and Bloom syndrome are rare, clinically distinct, chromosome instability syndromes. This Primer describes the understanding of the genetic and molecular basis of these disorders, including the relationship of the defects to the predisposition to cancer.