Reviews & Analysis

This PrimeView highlights the pathophysiology of medication overuse headache, a secondary headache disorder caused by overuse of acute headache medications by individuals with underlying headache disorders.

Medication overuse headache is a secondary headache disorder that occurs in those with a primary headache disorder (commonly tension-type headache or migraine). This Primer reviews the epidemiology, pathophysiology, diagnosis and treatment of medication overuse headache, and discusses how this disorder affects the quality of life of patients.

This PrimeView highlights the mechanisms of ichthyosis and summarizes its epidemiology, diagnosis and management. It accompanies the Primer on this topic by Gutiérrez-Cerrajero and colleagues.

The ichthyoses are a group of dermatological disorders characterized by generalized scaly, erythematous skin, accompanied by epidermal barrier function disruptions. This Primer by Gutiérrez-Cerrajero and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of ichthyosis, and discusses patient quality of life and open research questions for this condition.