A cartoon of the thyroid gland


Hypothyroidism is the common clinical condition of thyroid hormone deficiency and, if left untreated, can lead to serious adverse health effects on multiple organ systems.


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    Topics soon to be featured in the journal include Medication overuse headache, Pre-eclampsia, Fetal alcohol spectrum disorders and Monogenic diabetes.

  • A new Comment article discusses the need for diversity in clinical trial populations to minimize outcome disparities.

    Homogeneous clinical trial populations do not accurately represent the patient populations served. Diversity in research participation is needed to minimize outcome disparities and achieve social equity.

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    Finding it hard to navigate the flood of scientific literature? Take a look at this animation to learn how Nature Reviews can help you stay up-to-date in your field by filtering and highlighting the most impactful research, or visit www.springernature.com/naturereviews


  • The ichthyoses are a group of dermatological disorders characterized by generalized scaly, erythematous skin, accompanied by epidermal barrier function disruptions. This Primer by Gutiérrez-Cerrajero and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of ichthyosis, and discusses patient quality of life and open research questions for this condition.

    • Carlos Gutiérrez-Cerrajero
    • Eli Sprecher
    • Rogelio González-Sarmiento
  • Hazardous drinking and alcohol use disorder are associated with substantial harms to both the individual and others. This Primer discusses the epidemiology, mechanisms, diagnosis and management of these disorders, and also summarizes screening, prevention and the quality of life issues faced by individuals with these disorders.

    • James MacKillop
    • Roberta Agabio
    • Jürgen Rehm
  • Burkitt lymphoma is an aggressive form of B cell lymphoma that can affect children and adults. Its research has been central in advancing haematopathology and cancer research. This Primer by Siebert and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of this disorder, patient quality of life and open research questions.

    • Cristina López
    • Birgit Burkhardt
    • Reiner Siebert
  • Osteosarcoma is the most common primary malignant tumour of the bone. This Primer by Gorlick and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of this disorder as well as the quality of life of patients and open research questions.

    • Hannah C. Beird
    • Stefan S. Bielack
    • Richard Gorlick
  • Myelodysplastic syndromes (MDS) are a group of blood cancers involving dysregulated haematopoiesis, which may progress to acute myeloid leukaemia. This Primer provides an overview of the epidemiology, diagnosis, pathogenesis and management of MDS.

    • Huan Li
    • Fang Hu
    • Yang Liang
  • Asplenia and hyposplenism can have multiple and complex causes and lead to morbidity and mortality, especially owing to overwhelming post-splenectomy infections. In this Primer, Lenti and colleagues review epidemiology, pathophysiology, diagnosis and management of these conditions, and discuss patient quality of life and future strategies.

    • Marco Vincenzo Lenti
    • Sarah Luu
    • Antonio Di Sabatino
A group of women with diverse backgrounds and physiques are standing together, supporting each other and looking ahead.

Women’s health

Research into women’s health has suffered from historical neglect and lack of funding.


Nature Careers