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Growing evidence indicates that sexual and gender minority populations might be at greater risk of cardiovascular disease than the general population. Additional population and clinical health research is needed to inform the development of tailored, evidence-based interventions to promote the cardiovascular health of sexual and gender minority populations.
Common genetic variants, modifiable risk factors and a polygenic risk score all have important implications for disease susceptibility, severity and variability in hypertrophic cardiomyopathy.
A new machine learning risk-stratification model accurately predicts the 1-year risk of ischaemic and major bleeding events in patients with an acute coronary syndrome and might be useful to guide clinical decision-making and optimize the quality of care of these patients.
Tissue-resident macrophages form direct interactions with lymphatic endothelial cells and regulate the growth and sprouting of lymphatic vessels during development of the mammalian cardiac vasculature.
Antihypertensive therapy, particularly with the use of an angiotensin-converting enzyme inhibitor, improves outcomes in patients with hypertension and SARS-CoV-2 infection, who are susceptible to hyperinflammation and severe outcomes with COVID-19.
Alarmins released by infarcted myocardium stimulate B cells to differentiate into antibody-producing plasma cells, which then remotely drive the progression of atherosclerosis by producing autoantibodies that accumulate in pre-existing atherosclerotic plaques, increasing local inflammation and accelerating the progression towards a vulnerable plaque phenotype.
A new study shows that hydralazine, a drug used for the treatment of resistant hypertension and heart failure, can inhibit mitochondrial fission, thereby reducing cardiomyocyte death and myocardial infarct size after ischaemia–reperfusion injury in mice.
Mouse embryonic organoids that model cardiac development ex vivo could be used as a high-throughput, experimentally tractable system to evaluate crucial cell populations and environmental factors that contribute to normal and abnormal cardiogenesis.
In this Review, Padmanabhan and Dominiczak discuss how genomics has transformed our understanding of blood pressure regulation and hypertension, summarizing the current knowledge of blood pressure genomics and highlighting the opportunities and challenges for drug repurposing and pharmacogenomics for the treatment of hypertension.
In this Review, Lucia and colleagues discuss the epidemiological evidence on the benefits of major lifestyle interventions in the prevention and adjuvant treatment of hypertension, including regular physical exercise, body weight management, healthy diet, adequate sleep patterns, circadian entrainment and stress management. The authors also describe the main physiological mechanisms underlying these benefits.
Effective stroke prevention with oral anticoagulation is a cornerstone of the management of patients with atrial fibrillation. Caution is required in patients with atrial fibrillation at high risk of stroke and bleeding. In this Review, Lip and colleague discuss strategies for reducing the risk of stroke in patients with atrial fibrillation.
In this Review, Bax and colleagues summarize the effects of obesity and diabetes on myocardial structure and function and evaluate the role of multimodality cardiac imaging to elucidate the pathophysiology of myocardial dysfunction, prognosticate long-term clinical outcomes and potentially guide treatment strategies.
