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A screening platform using cell cultures derived from tumour biopsy samples identifies drug combinations that are effective in treating tumour resistance.
This paper finds that levels of histone H3 lysine 79 (H3K79) methylation affect the level of gene expression through the AF10–DOT1L complex, with implications for acute myeloid leukaemia therapy.
Data from three recent papers suggest that alterations of super-enhancers in cancer cells can promote oncogene expression and therapeutic resistance in some cases. Proteins that promote transcription from super-enhancers might be viable therapeutic targets.
Complementing government and industry funding, philanthropies have made distinct contributions to altering the trajectory of cancer research. This Science and Society article aims to investigate the changing role of philanthropy in fostering cancer research, with emphasis on the work of non-profit institutions.