Scheeren et al. have found a cell-intrinsic role for Toll-like receptor 2 (TLR2) in tumorigenesis. They found that ablation of Tlr2 or myeloid differentiation primary response gene 88 (Myd88; which functions downstream of TLR2) reduced inflammation-induced tumorigenesis of intestinal epithelium. Furthermore, deletion of Tlr2 and Myd88 in mammary epithelium reduced the mammary repopulating unit frequency, and TLR2 inhibition reduced the growth of human breast cancers.
References
Scheeren, F. A. et al. A cell-intrinsic role for TLR2–MYD88 in intestinal and breast epithelial and oncogenesis. Nature Cell Biol. http://dx.doi.org/10.1038/ncb3058 (2014)
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Alderton, G. Intrinsic intrigue. Nat Rev Cancer 14, 767 (2014). https://doi.org/10.1038/nrc3875
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DOI: https://doi.org/10.1038/nrc3875