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A paper published inNature Medicinereports on the results of treating patients with multiple myeloma with engineered T cells that recognise the cancer—testis antigen NY-ESO-1.
Two papers published inNature Geneticshave reported whole-genome and whole-exome sequencing of paired Barrett oesophagus and oesophageal adenocarcinoma (EAC) samples, providing some insights into the development of EAC from its precursor lesion.
Alekseyenko, Walshet al. have discovered that NUT fusion proteins, which underlie the development of the aggressive squamous cell cancer NUT midline carcinoma, localize to very large hyperacetylated domains within chromatin, which they term 'megadomains', leading to aberrant transcriptional programmes that promote tumorigenesis.
A paper published inMolecular Cell indicates that the production of ketones can promote the BRAFV600E–MEK–ERK oncogenic pathway and identifies a potential Achilles' heel.
Mohammedet al. have examined the functional interactions between oestrogen receptor-α (ERα) and progesterone receptor (PR) in mouse and human breast tumours. They found that activation of PR changes the pattern of ERα chromatin binding, resulting in the expression of antiproliferative genes.
A paper inNatureidentifies glypican 1 as a marker of circulating exosomes derived from pancreatic ductal adenocarcinoma (and from some breast cancers) that could be an effective biomarker for early diagnosis and treatment monitoring.
Inducible short hairpin RNA (shRNA)-mediated silencing of adenomatous polyposis coli (Apc) in the intestines of mice has revealed that APC loss is crucial for tumour maintenance even in the presence of other oncogenic mutations, and that re-expression of APC can restore normal crypt homeostasis.
Three papers now present different aspects of a similar story: altered splicing can lead to myelodysplastic syndrome (MDS) and even to progression to acute myeloid leukaemia (AML).
