Huang et al. have identified that the potassium channel ether-a-go-go 2 (EAG2) promotes tumour growth and metastasis in multiple fly and mouse brain tumour models. In a xenograft model of medulloblastoma, EAG2 knockdown impaired metastasis, and pharmacological inhibition of EAG2 with an FDA-approved antipsychotic drug, thioridazine, showed potent efficacy in reducing intracranial tumour growth and metastasis.
References
Huang, X. et al. EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. Nat. Neurosci. http:/dx.doi.org/10.1038/nn.4088 (2015)
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Villanueva, M. Reinventing the wheel. Nat Rev Cancer 15, 514 (2015). https://doi.org/10.1038/nrc4010
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DOI: https://doi.org/10.1038/nrc4010
