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Nie et al. performed metabolomics profiling on samples obtained from patients during the development of invasive lung adenocarcinoma and showed that metabolic pathways are progressively disrupted.
Hung, Yost, Xie et al. show that extrachromosomal DNAs (ecDNAs) are held together in hubs in the nucleus and that intermolecular interactions between ecDNAs can enhance oncogene expression.
In this Journal Club, Desiree Rivers discusses a study that developed and assessed the impact of SurvivorSHINE, a web-based lifestyle intervention for cancer survivors.
In this Journal Club, Ashktorab and Brim discuss a study that established consensus molecular subtypes for colorectal cancer (CRC) with potential for direct clinical translation and better classification of CRC.
Liu et al. show that glycogen accumulates in pre-malignant liver cells by undergoing liquid–liquid phase separation and, by sequestering Hippo kinases MST1 and MST2, promotes YAP-driven tumorigenesis.
Kaushik Tiwari et al. have developed a strategy to directly target amplified genes in cancer using triplex-forming oligonucleotides, which selectively induce DNA damage and apoptosis in cancer cells with copy number gains.
Guo et al. have developed a novel strategy, which involves coating tumour cells with silica, to enable personalized cancer vaccines to overcome the immunosuppressive effects of the tumour microenvironment.
Klemm et al. examined the role of tumour-associated macrophages (TAMs) at different stages of brain metastasis in mouse models and found that targeting TAMs by inhibiting both CSF1R and STAT5 might have long-lasting efficacy and prevent resistance.
This Review outlines our current understanding of the evolution and heterogeneity of pancreatic ductal adenocarcinoma (PDAC), which has advanced owing to the study of preclinical models and patient samples, and presents an evolutionary model of PDAC progression based primarily on genomics studies of human PDAC.
Pernigoni et al. present a unique mode of non-genetic resistance accounting for castration-resistant prostate cancer that is mediated by androgen-synthesizing gut microbiota.
This Perspective explores the connection between copper and cancer and how challenges in the field could be addressed, and is a synthesis of discussions from the Copper Cancer Consortium, a meeting of experts in the field that took place in March 2020.
Neuhöfer et al. have identified a rare subpopulation of pancreatic acinar cells in the exocrine compartment that renews the pancreas by fuelling clonal expansion. When harbouring Kras mutations, these acinar cells accelerated clone formation and might represent an early cancer precursor lesion.
Schneider et al. show that peripheral serotonin augments colorectal and pancreatic tumour growth in mice by increasing PDL1 expression on cancer cells, and in turn inhibiting the accumulation of functional CD8+ T cells within tumours.
Canale et al. engineered the bacterial strain Escherichia coli Nissle 1917 to recycle ammonia into arginine, and showed synergistic responses with anti-programmed cell death 1 ligand 1 therapy in tumour-bearing mice when injected intratumourally or given systemically.
Xu et al. have uncovered a novel and unexpected role for the ERα as a non-canonical RNA-binding protein, which functions to maintain breast cancer cell survival and tamoxifen resistance.
This Review discusses recent foundational and translational advances in gastric cancer genomics and epigenomics and highlights how these findings have improved our understanding of basic mechanisms driving gastric cancer biology as well as emerging preclinical targets.
This Review discusses the concept of transcription cycles in cancer, providing a framework for our understanding of dysregulated transcription in cancer and therapeutic targeting of dysregulated transcription cycles.
This Review discusses the context-dependent functions of transforming growth factor-β (TGFβ) with regard to the composition and behaviour of different cell populations in the tumour immune microenvironment, as well as emerging data that demonstrate that TGFβ inhibition can restore cancer immunity.
