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Ajona et al. have shown that short-term starvation can sensitize lung tumours in mice to the action of immune checkpoint blockade through a reduction in levels of circulating insulin-like growth factor 1 (IGF1).
Recent single-cell RNA-sequencing studies have revealed a range of intratumoural T cell states, both within and between patients. This Review outlines the CD8+ T cell states that have been identified in human tumours and the potential roles they play in tumour control as well as how they are influenced by immune checkpoint blockade.
A recent study from Ralph DeBerardinis’ and Sean Morrison’s labs has found that metastatic melanoma cells upregulate the lactate transporter MCT1 in vivo to manage oxidative stress, which allows them to survive during dissemination.
Sinha et al. systematically mapped genomic alterations in lung tumours from an ethnically unbiased patient cohort and demonstrated a higher frequency of homologous recombination deficiency in tumours from African Americans than European Americans, highlighting the need to include diverse populations in cancer genomics studies.
This Consensus Statement highlights the importance of cancer-associated fibroblasts in cancer biology and progression, and issues a call to action for all cancer researchers to standardize assays and report metadata in studies of cancer-associated fibroblasts to advance our understanding of this important cell type in the tumour microenvironment.
This Review discusses the role that nerves play in the initiation and progression of cancers, focusing on the evidence that tumours may reactivate nerve-mediated developmental and regenerative pathways to promote their own growth and survival.
This Perspective discusses how cell competition between tumour cells and neighbouring epithelial host cells may dictate tumorigenesis and proposes that manipulating the strength and direction of cell competition could form the basis of an orthogonal therapeutic strategy.
Jansen et al. show in patients with cancer that intratumoural stem-like CD8+ T cells reside in antigen-presenting cell (APC) niches in the tumour and give rise to terminally differentiated T cells.
This Review discusses many of the similarities and differences between leukaemia stem cells (LSCs) in chronic myeloid leukaemia and acute myeloid leukaemia and examines the therapeutic strategies that could be used to eradicate these LSCs.
