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Metaplastic breast carcinoma (MBC) accounts for 0.2–5% of invasive breast cancers. The majority of MBCs have a triple-negative phenotype, are highly heterogeneous and respond poorly to chemotherapy. Understanding their divergent differentiation and identifying the cell of origin might provide some much-needed insight into this disease.
NUT midline carcinoma, a squamous cell carcinoma, is one of the most aggressive human cancers, and there is a desperate need for effective therapies for patients with this disease.
Stage MS neuroblastoma is unique in that it regresses without treatment. Could a better understanding of the biology of these tumours inform how high-risk neuroblastoma and other paediatric malignancies are treated?
Cancer of unknown primary site is both a challenging clinical problem and a disease that provides potential insight into the mechanisms that underlie early metastasis.
Despite a ban on the use of plants of theAristolochiagenus in herbal medicine, as they contain known carcinogens, urothelial carcinoma attributable to the use of this plant seems to be more common than previously thought.
Can mathematical techniques allow substantial biological interrogation of the seed and soil hypothesis of metastasis by considering the properties of circulating tumour cells?
The seminal article by Douglas Hanahan and Robert Weinberg on the hallmarks of cancer is 10 years old this year and its contribution to how we see cancer has been substantial. But, in embracing this view, have we lost sight of what makes cancer cancer?